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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12492188 B1

PDFFull Text
Date of Patent:
Dec. 09, 2025

Filed:

Aug. 18, 2021

1h-benzo[d]imidazole derivatives as tlr9 inhibitors for the treatment of fibrosis

Applicant:

Bristol-myers Squibb Company, Princeton, NJ (US);

Inventors:

David S. Yoon, Ambler, PA (US);

Alicia Regueiro-Ren, New Hope, PA (US);

Michael Mandler, Lawrenceville, NJ (US);

Shoshana L. Posy, Highland Park, NJ (US);

Chunjian Liu, Pennington, NJ (US);

Assignee:

Bristol-Myers Squibb Company, Princeton, NJ (US);

Attorney:

Gary Greenblatt

Primary Examiner:

Joseph K Mckane

Assistant Examiner:

David M Shim

Int. Cl.
CPC ...
C07D 401/14 (2006.01); C07D 235/18 (2006.01); C07D 401/10 (2006.01); C07D 401/12 (2006.01); C07D 403/10 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01); C07D 451/02 (2006.01); C07D 451/04 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 487/10 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); C07D 235/18 (2013.01); C07D 401/10 (2013.01); C07D 401/12 (2013.01); C07D 403/10 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 451/02 (2013.01); C07D 451/04 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 487/10 (2013.01); C07D 519/00 (2013.01);
Abstract

The present invention relates to 1H-benzo[d]imidazole derivatives of formula (I) or a salt thereof. The present compounds are inhibitors of TLR9 and useful in treating preventing, or slowing fibrotic diseases, such as e.g. liver fibrosis, renal fibrosis, biliary fibrosis or pancreatic fibrosis, non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD), chronic kidney disease, diabetic kidney disease, primary sclerosing cholangitis (PSC) or primary biliary cirrhosis (PBC), or idiopathic pulmonary fibrosis (IPF).

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