The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 09, 2025

Filed:

Oct. 09, 2020
Applicant:

The General Hospital Corporation, Boston, MA (US);

Inventors:

Jacob M. Hooker, Charlestown, MA (US);

Changning Wang, Acton, MA (US);

Frederick Albert Schroeder, Baltimore, MA (US);

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 51/04 (2006.01); C07C 259/06 (2006.01); C07C 259/08 (2006.01); C07C 275/34 (2006.01); C07C 311/16 (2006.01); C07C 311/21 (2006.01); C07D 209/08 (2006.01); C07D 209/14 (2006.01); C07D 235/08 (2006.01); C07D 267/16 (2006.01); C07D 281/12 (2006.01);
U.S. Cl.
CPC ...
A61K 51/04 (2013.01); C07C 259/06 (2013.01); C07C 259/08 (2013.01); C07C 275/34 (2013.01); C07C 311/16 (2013.01); C07C 311/21 (2013.01); C07D 209/08 (2013.01); C07D 209/14 (2013.01); C07D 235/08 (2013.01); C07D 267/16 (2013.01); C07D 281/12 (2013.01); C07B 2200/05 (2013.01); C07C 2601/14 (2017.05); C07C 2602/10 (2017.05); C07C 2603/74 (2017.05);
Abstract

Disclosed herein are histone deacetylase imaging agents for positron emission tomography and related imaging methods using the histone deacetylase imaging agents. The histone deacetylase imaging agents may be a compound of formula (I): wherein Ris a moiety including a positron emitter; Rrepresents hydrogen, or substituted or unsubstituted alkyl, or substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and n is an integer selected from 0 or 1. In one version of the compound of formula (I), Ris a moiety including an adamantyl group.


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