The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 09, 2025
Filed:
Apr. 01, 2025
Applicant:
Imam Mohammad Ibn Saud Islamic University, Riyadh, SA;
Inventors:
Amin Osman Elzupir, Riyadh, SA;
Sondos A. J. Almahmoud, Riyadh, SA;
Assignee:
IMAM MOHAMMAD IBN SAUD ISLAMIC UNIVERSITY, Riyadh, SA;
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/15 (2006.01);
U.S. Cl.
CPC ...
A61K 31/15 (2013.01);
Abstract
A method of inhibiting a Programmed Cell Death Protein 1 (PD-1) or Programmed Death-Ligand 1 (PD-L1) protein includes reacting an N-(naphthyl)-ethylenediamine dihydrochloride (CHN·2HCl) with an aldehyde (R—CHO) in ethanol (CHCHOH) in the presence of sodium bicarbonate (NaHCO) to obtain a reaction mixture. The reaction mixture is then refluxed for 3 hours (h) to 7 h, yielding an aminoethyl Schiff base which is then contacted with PD-1 or PDL-1 protein to form a PD-1 or PDL-1 protein complex.