The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 02, 2025

Filed:

Apr. 10, 2020
Applicants:

University of Florida Research Foundation, Incorporated, Gainesville, FL (US);

The Research Foundation for the State University of New York, Albany, NY (US);

Inventors:

Thomas D. Bannister, Palm Beach Gardens, FL (US);

Chao Wang, Palm Beach Gardens, FL (US);

Agnieszka B. Bialkowska, East Setauket, NY (US);

Vincent W. Yang, East Setauket, NY (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 207/09 (2006.01); A61P 35/00 (2006.01); C07D 207/48 (2006.01); C07D 211/28 (2006.01); C07D 211/96 (2006.01); C07D 243/08 (2006.01); C07D 295/26 (2006.01);
U.S. Cl.
CPC ...
C07D 207/09 (2013.01); A61P 35/00 (2018.01); C07D 207/48 (2013.01); C07D 211/28 (2013.01); C07D 211/96 (2013.01); C07D 243/08 (2013.01); C07D 295/26 (2013.01);
Abstract

The present disclosure provides compounds of formula (I), as described herein, their pharmaceutically acceptable salts, and their pharmaceutical compositions, which are effective in reducing the expression level of KLF5 or EGR1 in a living cell, and for the treatment of tumors and colorectal cancer in a human patient.


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