The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 02, 2025

Filed:

Jun. 13, 2019
Applicant:

Texas Tech University System, Lubbock, TX (US);

Inventors:

Susan E. Bergeson, Lubbock, TX (US);

Ted W. Reid, Lubbock, TX (US);

Mayank Shashtri, Lubbock, TX (US);

Peter Syapin, Camarillo, CA (US);

Phat Tran, Lubbock, TX (US);

Assignee:

Texas Tech University System, Lubbock, TX (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07C 237/16 (2006.01); A61B 5/00 (2006.01); A61K 31/65 (2006.01); C07C 237/26 (2006.01); C07D 317/72 (2006.01);
U.S. Cl.
CPC ...
C07C 237/26 (2013.01); A61B 5/4848 (2013.01); A61K 31/65 (2013.01); C07D 317/72 (2013.01); C07C 2603/46 (2017.05);
Abstract

The present invention includes novel molecules and methods for using the same to treat Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising: identifying a subject in need of treatment for at least one of AUD, SUD, pain, or a proinflammatory disorder; and providing the subject with an effective amount of a modified minocycline to ameliorate or eliminate the AUD, SUD, pain, or proinflammatory disorder and that has reduced, or no, antimicrobial activity, wherein the modified tetracycline has a formula, e.g., or the modified doxycycline, minocycline, and tigecycline and their tautomerized structures, where the R-groups shown in the minocycline example above could be different combination of halogen, acetyl ester, methyl ester, and diacetal.


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