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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12485104 B1

PDFFull Text
Date of Patent:
Dec. 02, 2025

Filed:

Apr. 07, 2023

Amino acid derivatives containing a disulfanyl group as an inhibitor of nep and apn for the prevention and treatment of trigeminal nerve pain

Applicant:

Kos Therapeutics, Inc., Raleigh, NC (US);

Inventors:

Hervé Poras, Villepreux, FR;

Tanja Ouimet, Paris, FR;

Marie Claude Fournie Zaluski, Paris, FR;

Bernard Roques, Paris, FR;

Michel Wurm, Royat, FR;

Assignee:

KOS THERAPEUTICS, INC., Raleigh, NC (US);

Attorney:

MARSHALL, GERSTEIN & BORUN LLP

Primary Examiner:

Kevin E Weddington

Int. Cl.
CPC ...
A61K 31/265 (2006.01); A61K 31/00 (2006.01); A61K 31/135 (2006.01); A61K 31/138 (2006.01); A61K 31/195 (2006.01); A61K 31/197 (2006.01); A61K 31/36 (2006.01); A61K 31/485 (2006.01); A61K 31/53 (2006.01); A61K 31/55 (2006.01); A61K 31/5513 (2006.01); A61K 45/06 (2006.01); A61P 25/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/265 (2013.01); A61K 31/135 (2013.01); A61K 31/138 (2013.01); A61K 31/195 (2013.01); A61K 31/197 (2013.01); A61K 31/36 (2013.01); A61K 31/485 (2013.01); A61K 31/53 (2013.01); A61K 31/55 (2013.01); A61K 31/5513 (2013.01); A61K 31/658 (2023.05); A61K 45/06 (2013.01); A61P 25/06 (2018.01);
Abstract

The present invention concerns a pharmaceutically acceptable salt of a compound of the following formula (I): HN—CH(R)—CHS—S—CH—CH(R—CONH—CH(R)—COOR(I) and more particularly an acid addition salt thereof, and the compositions comprising the same, for use in the prevention or treatment of trigeminal nerve pain, in particular migraines or trigeminal neuralgia.

Find Patent Forward Citations

Poras, Hervé. (2025). Amino acid derivatives containing a disulfanyl group as an inhibitor of nep and apn for the prevention and treatment of trigeminal nerve pain (U.S. Patent No. 12485104). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12485104

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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