The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 25, 2025
Filed:
Apr. 22, 2021
Universite DE Strasbourg, Strasbourg, FR;
Institut National DE LA Sante ET DE LA Recherche Medicale, Paris, FR;
Institut Hospitalier Universitaire DE Strasbourg, Strasbourg, FR;
Icahn School of Medicine AT Mount Sinai, New York, NY (US);
Thomas Baumert, Freiburg, DE;
Yujin Hoshida, Englewood Cliffs, NJ (US);
Universite de Strasbourg, Paris, FR;
Institut National de la Sante et de la Recherche Medicale, Strasbourg, FR;
Institut Hospitalier Universitaire de Strasboug, Strasbourg, FR;
ICAHN School of Medicine at Mount Sinai, New York, NY (US);
Abstract
The present invention provides a simple and robust human liver cell-based system in which persistent hepatitis C infection, persistent hepatitis B infection or ethanol exposure induces a clinical Prognostic Liver Signature (PLS) high-risk gene signature. The cellular model system for hepatocellular carcinoma (HCC)/cirrhosis development and progression may be used in the screening of compounds useful in the treatment and/or prevention of cirrhosis and/or HCC as well as in the identification biomarkers for the prediction of liver disease (especially cirrhosis) progression and HCC. The present invention also relates to specific compounds that have been identified, using such screening methods, as useful in the treatment and/or the prevention of HCC/cirrhosis.