The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 25, 2025
Filed:
Nov. 12, 2020
Applicant:
Soochow University, Suzhou, CN;
Inventors:
Haibin Shi, Suzhou, CN;
Shuyue Ye, Suzhou, CN;
Assignee:
SOOCHOW UNIVERSITY, Suzhou, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 1/13 (2006.01); C07D 405/14 (2006.01); C07K 7/64 (2006.01); C09K 11/06 (2006.01);
U.S. Cl.
CPC ...
C09K 11/06 (2013.01); C07D 405/14 (2013.01); C07K 1/13 (2013.01); C07K 7/64 (2013.01); C09K 2211/1007 (2013.01); C09K 2211/1022 (2013.01);
Abstract
The present invention disclosed a red-light-mediated nucleic acid anchoring fluorescent probe and its preparation method and application. The fluorescent probe has the capability of taking a crosslinking reaction with RNA in cytoplasm under singlet oxygen mediation, and imaging of tumor tissues in a long window period is achieved. Moreover, it is found that by means of the probe, after crosslinking of RNA, a severe apoptosis phenomenon of tumor cells occurs, and the integration of diagnosis and treatment of tumors is achieved.