The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 25, 2025
Filed:
Feb. 22, 2021
Applicant:
Grifols Worldwide Operations Limited, Dublin, IE;
Inventors:
James Rebbeor, Research Triangle Park, NC (US);
Jeffrey A. Yuziuk, Research Triangle Park, NC (US);
George Grady, Research Triangle Park, NC (US);
Dennis Mcbride, Research Triangle Park, NC (US);
Assignee:
Grifols Worldwide Operations Limited, Dublin, IE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/81 (2006.01); A61K 38/55 (2006.01); A61P 11/00 (2006.01); B01D 61/14 (2006.01);
U.S. Cl.
CPC ...
C07K 14/8125 (2013.01);
Abstract
A method for obtaining Alpha-1 Proteinase Inhibitor for obtaining highly-concentrated Alpha-1 Proteinase Inhibitor (A1PI) includes preparing a solution of A1PI by concentrating an initial solution of A1PI by tangential flow filtration (TFF) against water. The final concentration of A1PI in the concentrated solution is at least 110 mg/ml. The TFF can be carried out against water for injection (WFD).