The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 25, 2025

Filed:

Feb. 28, 2020
Applicant:

Universiteit Gent, Ghent, BE;

Inventors:

Annemieke Madder, Massemen, BE;

Ewout De Geyter, Laarne, BE;

Eirini Antonatou, Ghent, BE;

Sabina Smolen, Pawonkow, PL;

Dimitris Kalaitzakis, Iraklion, GR;

Georgios Vassilikogiannakis, Iraklion, GR;

Assignee:

Universiteit Gent, Ghent, BE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 207/38 (2006.01); A61K 47/60 (2017.01); C07D 207/44 (2006.01); C07D 207/48 (2006.01);
U.S. Cl.
CPC ...
C07D 207/38 (2013.01); A61K 47/60 (2017.08); C07D 207/44 (2013.01); C07D 207/48 (2013.01);
Abstract

The present invention in general relates to the field of bioconjugation. More in particular, the invention relates to novel bioconjugation reactants based on an α,β unsaturated γ-hydroxylactam structure, amongst others allowing a higher degree of functionalization compared to classical bioconjugation reactants such as maleimide. The present invention also provides methods of preparing the novel bioconjugation reactants, as well as uses thereof in human and/or veterinary medicine; and conjugation processes.


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