The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 25, 2025
Filed:
Sep. 25, 2020
Applicant:
Intra-cellular Therapies, Inc., New York, NY (US);
Inventors:
Robert E. Davis, San Diego, CA (US);
Gretchen Snyder, New York, NY (US);
Peng Li, New Milford, NJ (US);
Assignee:
INTRA-CELLULAR THERAPIES, INC., Bedminster, NJ (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/4985 (2006.01); A61K 45/06 (2006.01); A61P 25/08 (2006.01); C07D 471/16 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4985 (2013.01); A61K 45/06 (2013.01); A61P 25/08 (2018.01); C07D 471/16 (2013.01);
Abstract
The disclosure provides methods for the for treatment of psychosis, such as schizophrenia, or depression (such as bipolar depression) and/or anxiety, comprising administering to a patient in need thereof, (i) a 5-HTor 5-HT/D2 receptor ligand, for example a substituted heterocycle fused gamma-carboline as described herein, in free, pharmaceutically acceptable salt or prodrug form, and (ii) a nitric oxide donor, separately (sequentially or simultaneously), or in combination (e.g., in a fixed dose combination).