The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 25, 2025
Filed:
Jul. 09, 2020
Applicant:
Children's Hospital Medical Center, Cincinnati, OH (US);
Inventors:
David A. Hildeman, Cincinnati, OH (US);
Andrew Herr, Cincinnati, OH (US);
Suhas G. Kallapur, Cincinnati, OH (US);
Jarek Meller, Cincinnati, OH (US);
Alexander Thorman, Cincinnati, OH (US);
Assignee:
Children's Hospital Medical Center, Cincinnati, OH (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/382 (2006.01); A61K 31/353 (2006.01); A61K 47/69 (2017.01); A61P 31/04 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/382 (2013.01); A61K 31/353 (2013.01); A61K 47/6913 (2017.08);
Abstract
The disclosure provides compounds of Formula I and their use in methods of modulating an immune response by inhibiting BFL1, and related methods for treating and preventing diseases and disorders characterized by inflammation, especially neutrophil induced inflammation.