The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 25, 2025
Filed:
Sep. 05, 2019
Tsubota Laboratory, Inc., Tokyo, JP;
Shinichi Ikeda, Tokyo, JP;
Xiaoyan Jiang, Tokyo, JP;
Kazuo Tsubota, Tokyo, JP;
Toshihide Kurihara, Tokyo, JP;
TSUBOTA LABORATORY, INC., Tokyo, JP;
Abstract
A model that closely resembles human excessive myopia can be prepared by mounting a minus lens () and a protector () to a juvenile mouse, the minus lens having an angle and a width adjustable in response to growth of the mouse. Further, this model analysis shows that myopia induction causes endoplasmic reticulum stress in a sclera and the endoplasmic reticulum stress induces myopia. Furthermore, it is revealed that an endoplasmic reticulum stress suppressant, particularly, phenylbutyrate and tauroursodeoxycholic acid act as a myopia prevention/suppression agent.