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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12478405 B1

PDFFull Text
Date of Patent:
Nov. 25, 2025

Filed:

Feb. 02, 2024

Centrifuge-free sperm preparation in an intelligent automated in vitro fertilization and intracytoplasmic sperm injection platform

Applicant:

Conceivable Life Sciences Inc., New York, NY (US);

Inventors:

Jacques Cohen, New York, NY (US);

Alejandro Chavez-Badiola, Mexico City, MX;

Gerardo Mendizabal-Ruiz, Guadalajara, MX;

Cesar Millan, Zapopan, MX;

Roberto Valencia-Murillo, Las Paz, MX;

Vladimir C. Ocegueda Hernandez, Zapopan, MX;

Nuno Costa-Borges, Barcelona, ES;

Victor Manuel Medina Perez, Guadalajara, MX;

Victor Manuel Rico Botero, Guadalajara, MX;

William Nicholas Garbarini, Jr., Cranford, NJ (US);

Assignee:

Conceivable Life Sciences Inc., New York, NY (US);

Attorney:

Miller Johnson

Primary Examiner:

Jason M Sims

Int. Cl.
CPC ...
A61B 17/43 (2006.01); A61B 17/425 (2006.01); A61B 34/30 (2016.01); C12M 1/00 (2006.01); C12M 1/02 (2006.01); C12M 1/22 (2006.01); C12M 1/26 (2006.01); C12M 1/36 (2006.01); C12M 3/00 (2006.01); C12N 5/073 (2010.01); G01N 1/10 (2006.01); G01N 33/50 (2006.01); G01N 35/00 (2006.01); G01N 35/10 (2006.01); G06T 7/20 (2017.01); G06T 7/70 (2017.01); G06V 10/82 (2022.01); G06V 20/69 (2022.01); A61B 34/32 (2016.01);
U.S. Cl.
CPC ...
A61B 17/43 (2013.01); A61B 17/425 (2013.01); A61B 34/30 (2016.02); C12M 21/06 (2013.01); C12M 23/10 (2013.01); C12M 23/48 (2013.01); C12M 23/50 (2013.01); C12M 33/04 (2013.01); C12M 41/06 (2013.01); C12M 41/18 (2013.01); C12M 41/48 (2013.01); C12N 5/0604 (2013.01); G01N 33/5091 (2013.01); G01N 35/0099 (2013.01); G01N 35/10 (2013.01); G01N 35/1011 (2013.01); G06T 7/20 (2013.01); G06T 7/70 (2017.01); G06V 10/82 (2022.01); G06V 20/693 (2022.01); A61B 34/32 (2016.02); G06T 2207/20081 (2013.01); G06T 2207/30024 (2013.01); G06V 20/69 (2022.01); G06V 20/698 (2022.01); G06V 2201/03 (2022.01);
Abstract

A method of artificial-intelligence-based robotic pipetting for spermatozoa preparation includes positioning a vessel containing a semen sample within a staging mechanism. The method includes using a robotic pipettor to make at least two droplets within a dish on the staging mechanism. The method includes using the robotic pipettor to connect the at least two droplets with a medium channel according to a programmable design commanded by an artificial intelligence/machine learning system (AI/ML system). The method includes using the robotic pipettor to deposit a quantity of sperm from the semen sample into one of the droplets. The method includes using the AI/ML system to optically scan the quantity of sperm to produce first and second image objects using an imaging system that includes a microscopy system, a camera system, and a lighting system. Creation of the image objects is separated by a specified time duration.

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