The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 18, 2025

Filed:

Nov. 14, 2017
Applicant:

Bruker Switzerland Ag, Faellanden, CH;

Inventors:

Felix Meissner, Berlin, DE;

Matthias Mann, Munich, DE;

Florian Meier, Pullach, DE;

Sebastian Virreira Winter, Munich, DE;

Arturo Zychlinsky, Berlin, DE;

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07C 317/04 (2006.01); C07D 211/94 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6848 (2013.01); C07C 317/04 (2013.01); C07D 211/94 (2013.01);
Abstract

The present invention relates to a compound which comprises or consists of (a) a reactive moiety, said reactive moiety being capable of reacting with a functional group of a peptide to form a covalent bond; and covalently joined thereto (b) a moiety which fragments in the mass spectrometer (i) at an energy below the energy required for fragmenting peptides and/or a higher conversion rate than peptides; and (ii) at said energy according to (i) and when coupled to a peptide via said reactive group, at a single site within said compound coupled to a peptide, to yield a first moiety and a second moiety, said second moiety being coupled to said peptide.


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