The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 18, 2025
Filed:
Feb. 11, 2021
Bristol-myers Squibb Company, Princeton, NJ (US);
Kumaravel Selvakumar, Bangalore, IN;
Venkatram Reddy Paidi, Kamareddy, IN;
Srinivasan Thangathirupathy, Hosur, IN;
Vijaya Kumar Cm, Hosur, IN;
Tirupathi Rao Alajangi, Vizianagaram, IN;
Mallikarjun Reddy Sura, Kadapa, IN;
Krishna Mahadevu, Mandya, IN;
Ramesh Kumar Sistla, Bangalore, IN;
Piyush Agarwal, Jodhpur, IN;
Arul Mozhi Subbiah Karuppiah, Bangalore, IN;
Jalathi S. Nair, Bangalore, IN;
Ooha Morampudi, Khammam, IN;
Manoranjan Panda, Bangalore, IN;
Joseph A. Tino, Lawrenceville, NJ (US);
Robert J. Cherney, Newtown, PA (US);
John V. Duncia, Newtown, PA (US);
Daniel S. Gardner, Furlong, PA (US);
T. G. Murali Dhar, Newtown, PA (US);
Audrey Graham Ross, Cambridge, MA (US);
Paul E. Gormisky, Belmont, MA (US);
Xiao Zhu, Winchester, MA (US);
Boris M. Seletsky, Andover, MA (US);
Alyssa H. Antropow, Boston, MA (US);
Deqiang Niu, Lexington, MA (US);
Zhengdong Zhu, Westborough, MA (US);
Guobin Miao, Lexington, MA (US);
Julio Hernan Cuervo, Arlington, MA (US);
Bristol-Myers Squibb Company, Princeton, NJ (US);
Abstract
wherein and X-Xand R-R, along with other variables are as defined herein. The disclosure generally relates to substituted heterocyclic compounds of Formula (Ia), which are inhibitors of PAD4, method for preparing these compounds, pharmaceutical compositions comprising these compounds and use of these compounds in the treatment of a disease or a disorder associated with PAD4 enzyme activity.