The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 18, 2025
Filed:
Oct. 12, 2020
Nanjing Sanhome Pharmaceutical Co., Ltd., Jiangsu, CN;
Yong Wang, Jiangsu, CN;
Liwen Zhao, Jiangsu, CN;
Xu Quan, Jiangsu, CN;
Guochuang Zheng, Jiangsu, CN;
Wei Sun, Jiangsu, CN;
Tingting Yang, Jiangsu, CN;
Kangning Zhan, Jiangsu, CN;
Qiqi Shi, Jiangsu, CN;
NANJING SANHOME PHARMACEUTICAL CO., LTD., Jiangsu, CN;
Abstract
The present invention belongs to the field of medicinal chemistry and relates to a class of substituted tricyclic compounds as PRMT5 inhibitors and the use thereof. Specifically, the present invention provides a compound represented by formula (A) or an isomer, pharmaceutically acceptable salt, solvate, crystal or prodrug thereof, a preparation method therefor, a pharmaceutical composition containing the compounds, and the use of the compounds or the composition for treating a disease mediated by PRMT5. The compounds of the present invention show significant inhibitory activity on PRMT5.