The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 18, 2025
Filed:
Apr. 16, 2020
Provincial Health Services Authority, Vancouver, CA;
The University of British Columbia, Vancouver, CA;
Kuo-Shyan Lin, Richmond, CA;
François Bénard, Vancouver, CA;
Hsiou-Ting Kuo, Sherbrooke, CA;
Helen Merkens, Burnaby, CA;
Zhengxing Zhang, Vancouver, CA;
PROVINCIAL HEALTH SERVICES AUTHORITY, Vancouver, CA;
THE UNIVERSITY OF BRITISH COLUMBIA, Vancouver, CA;
Abstract
This application relates to compounds of Formula I. R, Rand Ris —COH, —SOH, —SOH, —SOH, —POH, —POH or —POH. Ris a linker, e.g. butylene. Ris a linkage, e.g. —O—, —S—, —S(O)—, S(O)—, —NHC(O)—, —C(O)NH—, or 1,2,3-triazole. R4 is —(CH)CH(R)(CH)— wherein Ris —(CH)CHor certain aromatic fused-ring systems. Rand Rare hydrogen or methyl. Each Xaa(if present) is an amino acid. Ris a radiolabeling group, e.g.: a radiometal chelator optionally bound by a radiometal; an aryl substituted with a radioisotope; a prosthetic group containing a trifluoroborate; or a prosthetic group containing a silicon-fluorine-acceptor moiety. The compounds may be useful for imaging prostate-specific membrane antigen (PSMA)-expressing tissues or for treating PSMA-expressing diseases (e.g. cancer).