The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 18, 2025
Filed:
Feb. 26, 2020
Applicant:
Oregon Health & Science University, Portland, OR (US);
Inventors:
Jeffrey Tyner, Portland, OR (US);
Tamilla Nechiporuk, Portland, OR (US);
Stephen Kurtz, Portland, OR (US);
Shannon Mcweeny, Portland, OR (US);
Assignee:
Oregon Health & Science University, Portland, OR (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/496 (2006.01); A61K 31/437 (2006.01); A61K 31/4545 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61K 31/635 (2006.01); A61P 35/02 (2006.01);
U.S. Cl.
CPC ...
A61K 31/496 (2013.01); A61K 31/437 (2013.01); A61K 31/4545 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 31/635 (2013.01); A61P 35/02 (2018.01);
Abstract
The present invention concerns novel methods of treatment for venetoclax-resistant acute myeloid leukemia, particularly in subjects with a low expression of TP53 protein or expression of TP53 protein associated with a mutation of the TP53 gene, the methods comprising administering to the subject in need thereof a therapeutically effective amount of a NTRK/ALK/ROS1 inhibitor, or a pharmaceutically acceptable salt thereof.