The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 18, 2025

Filed:

May. 20, 2024
Applicant:

Antecip Bioventures Ii Llc, New York, NY (US);

Inventor:

Herriot Tabuteau, New York, NY (US);

Assignee:

Antecip Bioventures II LLC, New York, NY (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/137 (2006.01); A61K 9/20 (2006.01); A61K 31/135 (2006.01); A61K 31/4525 (2006.01); A61K 31/485 (2006.01); A61P 25/24 (2006.01); G01N 33/94 (2006.01);
U.S. Cl.
CPC ...
A61K 31/137 (2013.01); A61K 9/2009 (2013.01); A61K 9/2013 (2013.01); A61K 9/2027 (2013.01); A61K 9/2054 (2013.01); A61K 9/2086 (2013.01); A61K 31/135 (2013.01); A61K 31/4525 (2013.01); A61K 31/485 (2013.01); A61P 25/24 (2018.01); G01N 33/942 (2013.01); A61K 9/20 (2013.01); G01N 2800/52 (2013.01);
Abstract

This disclosure relates to administration of a combination of: 1) about 100-110 mg, about 104-106 mg, or about 105 mg of bupropion hydrochloride, or a molar equivalent amount of a free base form or another salt form of bupropion; and 2) about 40-50 mg, about 44-46 mg, or about 45 mg of dextromethorphan hydrobromide, or a molar equivalent amount of a free base form or another salt form of dextromethorphan in certain patient populations, such as patients having moderate renal impairment, patients receiving a concomitant strong CYP2D6 inhibitor, patients who are known CYP2D6 poor metabolizers, those in need of an NMDA antagonist that does not cause dissociation, and those at risk of QT prolongation.


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