The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 18, 2025

Filed:

Apr. 21, 2022
Applicant:

Celanese Eva Performance Polymers Llc, Irving, TX (US);

Inventors:

Christian Schneider, Hattersheim, DE;

Jeffrey C. Haley, Norwood, OH (US);

Dirk Hair, Edmonton, CA;

Harsh Patel, Union, KY (US);

Vijay Gyanani, Powell, OH (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/48 (2006.01); A61K 47/26 (2006.01); A61K 47/32 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
A61K 9/4816 (2013.01); A61K 47/26 (2013.01); A61K 47/32 (2013.01); C07K 16/2818 (2013.01); C07K 16/2827 (2013.01);
Abstract

An implantable device for delivery of a macromolecular drug compound is provided. The device comprises a core having an outer surface and a membrane layer positioned adjacent to the outer surface of the core. The core comprises a core polymer matrix within which is dispersed a drug compound having a molecular weight of about 0.5 kDa or more, the polymer matrix containing a hydrophobic polymer. Further, the membrane layer comprises a plurality of water-soluble particles distributed within a membrane polymer matrix containing an ethylene vinyl acetate copolymer, wherein the water-soluble particles have a D50 particle size of about 150 micrometers or less and contain a non-polymeric, hydroxy-functional compound.


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