The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 11, 2025

Filed:

Dec. 15, 2022
Applicant:

Quantum-si Incorporated, Guilford, CT (US);

Inventors:

Jonathan M. Rothberg, Miami Beach, FL (US);

Michael Meyer, Guilford, CT (US);

Umut Eser, Lexington, MA (US);

Assignee:

Quantum-Si Incorporated, Guilford, CT (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/48 (2006.01); G01N 21/64 (2006.01); G01N 33/50 (2006.01); G06N 3/047 (2023.01); G06N 20/00 (2019.01); G16B 30/10 (2019.01); G16B 30/20 (2019.01); G16B 40/10 (2019.01); G16B 40/20 (2019.01); G16B 45/00 (2019.01); C12Q 1/6869 (2018.01); C12Q 1/6874 (2018.01); G16B 40/30 (2019.01);
U.S. Cl.
CPC ...
G16B 30/10 (2019.02); G01N 21/6428 (2013.01); G06N 3/047 (2023.01); G06N 20/00 (2019.01); G16B 30/20 (2019.02); G16B 40/10 (2019.02); G16B 40/20 (2019.02); G16B 45/00 (2019.02); C12Q 1/6869 (2013.01); C12Q 1/6874 (2013.01); G16B 40/30 (2019.02);
Abstract

A method includes obtaining, from one or more sequencing devices, raw data detected from luminescent labels associated with nucleotides during nucleotide incorporation events; and processing the raw data to perform a comparison of base calls produced by a learning enabled, automatic base calling module of the one or more sequencing devices with actual values associated with the raw data, wherein the base calls identify one or more individual nucleotides from the raw data. Based on the comparison, an update to the learning enabled, automatic base calling module is created using at least some of the obtained raw data, and the update is made available to the one or more sequencing devices.


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