The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 11, 2025

Filed:

Oct. 24, 2023
Applicant:

West Virginia University Board of Governors on Behalf of West Virginia University, Morgantown, WV (US);

Inventors:

Ali R. Rezai, Morgantown, WV (US);

Victor Finomore, Jr., Morgantown, WV (US);

Jeff Carpenter, Morgantown, WV (US);

Marc Haut, Morgantown, WV (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/00 (2006.01); A61K 9/50 (2006.01); A61N 7/00 (2006.01); A61N 7/02 (2006.01); C07K 16/18 (2006.01); G01N 29/34 (2006.01); G01N 33/53 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6896 (2013.01); A61K 9/50 (2013.01); A61N 7/00 (2013.01); A61N 7/02 (2013.01); C07K 16/18 (2013.01); G01N 29/34 (2013.01); G01N 33/53 (2013.01); A61N 2007/0021 (2013.01); A61N 2007/0026 (2013.01); A61N 2007/0039 (2013.01); G01N 2800/28 (2013.01);
Abstract

A method of improving a neurodegenerative or cognitive disorder in a human patient suffering therefrom is provided by determining a target site of the human patient's brain that is affected by the neurodegenerative disorder or cognitive disorder and providing a therapy to the human patient. The therapy includes applying a low intensity focused ultrasound (LiFUS) sonication via an ultrasound delivery device to the target site based on an imaging parameter, a microbubble cavitation; an optical parameter, a bodily fluid parameter, or a physiological or anatomical parameter of the human patient's brain. A therapeutic agent is introduced to the target site before, after or during application of the LiFUS sonication.


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