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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12467920 B1

PDFFull Text
Date of Patent:
Nov. 11, 2025

Filed:

Apr. 22, 2021

Nanocomposites and nanoagents for detection and treatment of a target of interest and methods of making and using same

Applicant:

Board of Trustees of the University of Arkansas, Little Rock, AR (US);

Inventors:

Alexandru S. Biris, Little Rock, AR (US);

Zeid Nima, Little Rock, AR (US);

Assignee:

BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, Little Rock, AR (US);

Attorneys:

troutman pepper locke

Tim Tingkang Xia, Esq.

Primary Examiner:

Carlos A Azpuru

Assistant Examiner:

Casey S Hagopian

Int. Cl.
CPC ...
G01N 33/553 (2006.01); A61K 9/00 (2006.01); A61K 31/337 (2006.01); A61K 31/704 (2006.01); A61K 41/00 (2020.01); A61K 47/68 (2017.01); A61K 47/69 (2017.01); A61K 49/00 (2006.01); B01J 13/02 (2006.01); B01J 13/06 (2006.01); B01J 13/20 (2006.01); B01J 13/22 (2006.01); B32B 15/02 (2006.01); B82Y 5/00 (2011.01); B82Y 15/00 (2011.01); B82Y 30/00 (2011.01); B82Y 40/00 (2011.01); G01N 33/531 (2006.01); G01N 33/574 (2006.01); H01F 1/00 (2006.01); A61N 1/40 (2006.01);
U.S. Cl.
CPC ...
G01N 33/553 (2013.01); A61K 31/337 (2013.01); A61K 31/704 (2013.01); A61K 41/0052 (2013.01); A61K 47/6849 (2017.08); A61K 47/6923 (2017.08); A61K 49/0065 (2013.01); B01J 13/02 (2013.01); B01J 13/06 (2013.01); B01J 13/20 (2013.01); B01J 13/22 (2013.01); B32B 15/02 (2013.01); G01N 33/531 (2013.01); G01N 33/57492 (2013.01); H01F 1/0054 (2013.01); A61K 9/0092 (2013.01); A61N 1/406 (2013.01); B82Y 5/00 (2013.01); B82Y 15/00 (2013.01); B82Y 30/00 (2013.01); B82Y 40/00 (2013.01);
Abstract

A nanoagent for detections and treatments of multiple targets of interest includes multiple types of nanocomposites, each type of nanocomposites comprising at least one nanostructure, each nanostructure having a core and a shell surrounding the core; a respective reporter assembled on the shell of each nanostructure; and a layer of a respective treating agent and a respective targeting agent conjugated to the respective reporter. In use, each type of nanocomposite targets to a respective target of interest according to the respective targeting agent and releases the respective treating agent and the nanostructure therein for therapeutic treatment of the respective target of interest, and the respective target of interest transmits at least one signature responsive to the respective reporter for detection of the respective target of interest.

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