The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 11, 2025
Filed:
Feb. 14, 2019
Applicant:
Sunnybrook Research Institute, Toronto, CA;
Inventors:
Juan Carlos Zuniga-Pflucker, Toronto, CA;
Mahmood Mohtashami, Toronto, CA;
Ashton Trotman-Grant, Toronto, CA;
Assignee:
Sunnybrook Research Institute, Toronto, CA;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 40/11 (2025.01); A61K 40/40 (2025.01); A61K 48/00 (2006.01); C12N 5/0783 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0636 (2013.01); A61K 40/11 (2025.01); A61K 40/40 (2025.01); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05); C12N 2501/42 (2013.01); C12N 2506/45 (2013.01);
Abstract
A method of generating cells of the T cell lineage is provided comprising (a) culturing a sample comprising stem cells or progenitor cells with a Notch ligand conjugated to a suspension support and (b) isolating cells of the T cell lineage. In one embodiment, the cells of the T-cell lineage are progenitor T cells or mature T cells. Compositions, kits and uses thereof are also provided.