The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 11, 2025
Filed:
Dec. 08, 2021
Medimmune Llc, Gaithersburg, MD (US);
Sanjeev Ahuja, Gaithersburg, MD (US);
Wai Keen Chung, Gaithersburg, MD (US);
Deborah Sweet Goldberg, Gaithersburg, MD (US);
Michael Handlogten, Gaithersburg, MD (US);
Someet Narang, Gaithersburg, MD (US);
Brian Russell, Gaithersburg, MD (US);
Min Zhu, Gaithersburg, MD (US);
Suzanne Hudak, Gaithersburg, MD (US);
Kenneth Hwang, Gaithersburg, MD (US);
Jihong Wang, Gaithersburg, MD (US);
MEDIMMUNE LLC, Gaithersburg, MD (US);
Abstract
Disclosed are methods for testing the presence and/or activity of glutathione system components and thioredoxin system components during the manufacturing process of disulfide bond-containing proteins. Also disclosed are methods for mitigating reduction of disulfide bonds during the manufacturing process, and for lowering the reduction potential of disulfide bond-containing proteins. Provided are compositions, kits, and methods for mitigating reduction and diminishing reduction potential of disulfide bond-containing proteins during protein manufacturing processes.