The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 11, 2025
Filed:
Nov. 15, 2019
Merck Sharp & Dohme Llc, Rahway, NJ (US);
Zachary G. Brill, Boston, MA (US);
Amjad Ali, Freehold, NJ (US);
Jared Cumming, Winchester, MA (US);
Duane Demong, Hanover, MA (US);
Qiaolin Deng, Edison, NJ (US);
Thomas H. Graham, Somerville, MA (US);
Rongze Kuang, Green Brook, NJ (US);
Yeon-Hee Lim, South San Francisco, CA (US);
Christopher W. Plummer, Cranford, NJ (US);
Jenny Lorena Rico Duque, Boston, MA (US);
Huijun Wang, Westfield, NJ (US);
Yonglian Zhang, East Brunswick, NJ (US);
Kake Zhao, Westfield, NJ (US);
Merck Sharp & Dohme LLC, Rahway, NJ (US);
Abstract
In its many embodiments, the present invention provides certain substituted amino triazolopyrimidine and amino triazolopyrazine compounds of Formula (IA) and Formula (IB): or and pharmaceutically acceptable salts thereof, wherein, R, R, and Rare as defined herein, pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other therapeutically active agents), and methods for their preparation and use, alone and in combination with other therapeutic agents, as antagonists of A2a and/or A2b receptors, and their use in the treatment of a variety of diseases, conditions, or disorders that are mediated, at least in part, by the adenosine A2a receptor and/or the adenosine A2b receptor.