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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12466820 B1

PDFFull Text
Date of Patent:
Nov. 11, 2025

Filed:

May. 28, 2020

Amino quinazoline derivatives as p2x3 inhibitors

Applicant:

Chiesi Farmaceutici S.p.a., Parma, IT;

Inventors:

Paolo Bruno, Parma, IT;

Matteo Biagetti, Parma, IT;

Claudio Fiorelli, Parma, IT;

Daniela Pizzirani, Parma, IT;

Daniele Pala, Parma, IT;

Paolo Ronchi, Parma, IT;

Charles Baker-Glenn, Parma, IT;

Hervè Van De Poël, Parma, IT;

Kim Louise Hirst, Parma, IT;

Sara Guariento, Parma, IT;

Assignee:

CHIESI FARMACEUTICI S.P.A., Parma, IT;

Attorney:

Sterne, Kessler, Goldstein & Fox P.L.L.C.

Primary Examiner:

Taylor V Oh

Int. Cl.
CPC ...
C07D 417/12 (2006.01); C07D 239/94 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); C07D 405/14 (2006.01); C07D 409/12 (2006.01); C07D 409/14 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01); C07D 487/04 (2006.01); C07F 5/02 (2006.01);
U.S. Cl.
CPC ...
C07D 417/12 (2013.01); C07D 239/94 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 487/04 (2013.01); C07F 5/02 (2013.01);
Abstract

The present invention relates to compounds of formula I inhibiting P2X purinoceptor 3; particularly the invention relates to compounds that are amino quinazoline derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of many disorders associated with P2Xreceptors mechanisms, such as respiratory diseases including cough, asthma, idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).

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