The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 11, 2025
Filed:
Apr. 28, 2022
Applicant:
The Regents of the University of Michigan, Ann Arbor, MI (US);
Inventors:
Tomasz Cierpicki, Ann Arbor, MI (US);
Jolanta Grembecka, Ann Arbor, MI (US);
Weijiang Ying, Ann Arbor, MI (US);
Yiwu Yao, Ann Arbor, MI (US);
Felicia Gray, Ann Arbor, MI (US);
Qingjie Zhao, Ann Arbor, MI (US);
Assignee:
The Regents of the University of Michigan, Ann Arbor, MI (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 403/14 (2006.01); A61K 9/00 (2006.01); A61K 45/06 (2006.01); C07D 403/04 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); C07D 471/16 (2006.01); C07D 493/10 (2006.01); C07D 498/06 (2006.01); C07D 498/16 (2006.01); C07D 513/16 (2006.01);
U.S. Cl.
CPC ...
C07D 403/14 (2013.01); C07D 403/04 (2013.01); C07D 405/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 471/16 (2013.01); C07D 493/10 (2013.01); C07D 498/06 (2013.01); C07D 498/16 (2013.01); C07D 513/16 (2013.01); A61K 9/0019 (2013.01); A61K 9/0053 (2013.01); A61K 45/06 (2013.01);
Abstract
Provided herein are small molecule inhibitors of Polycomb Repressive Complex 1 (PRC1) activity, and methods of use thereof for the treatment of disease, including leukemia and other cancers, as well as other diseases dependent on the activity of PRC1.