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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12466808 B1

PDFFull Text
Date of Patent:
Nov. 11, 2025

Filed:

Feb. 08, 2021

Aminopyridine derivatives and their use as selective alk-2 inhibitors

Applicant:

Novartis Ag, Basel, CH;

Inventors:

Luca Arista, Riehen, CH;

Sreehari Babu, Hyderabad, IN;

Jianwei Bian, Jiangsu Province, CN;

Kai Cui, Jiangsu Province, CN;

Michael Patrick Dillon, Castro Valley, CA (US);

Rene Lattmann, Oberwil, CH;

Jialiang Li, Jiangsu Province, CN;

Lv Liao, Shanghai, CN;

Dimitrios Lizos, Basel, CH;

Rita Ramos, Allschwil, CH;

Nikolaus Johannes Stiefl, Lörrach, DE;

Thomas Ullrich, Bottmingen, CH;

Peggy Usselmann, Wahlbach, FR;

Xiaoyang Wang, Shanghai, CN;

Liladhar Murlidhar Waykole, Succasunna, PA (US);

Sven Weiler, Lörrach, DE;

Yubo Zhang, Shanghai, CN;

Yizong Zhou, Shanghai, CN;

Tingying Zhu, Shanghai, CN;

Assignee:

NOVARTIS AG, Basel, CH;

Attorneys:

Brian C. Trinque

Nicole Sassu

Lathrop GPM LLP

Primary Examiner:

James H Alstrum-Acevedo

Assistant Examiner:

Pierre Paul Eleniste

Int. Cl.
CPC ...
C07D 401/14 (2006.01); A61P 19/00 (2006.01); A61P 19/08 (2006.01); C07D 213/82 (2006.01); C07D 401/10 (2006.01); C07D 401/12 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 411/14 (2006.01); C07D 413/00 (2006.01); C07D 413/10 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/00 (2006.01); C07D 419/00 (2006.01); C07D 491/107 (2006.01); C07D 491/20 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); A61P 19/00 (2018.01); A61P 19/08 (2018.01); C07D 213/82 (2013.01); C07D 401/10 (2013.01); C07D 401/12 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 411/14 (2013.01); C07D 413/00 (2013.01); C07D 413/10 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/00 (2013.01); C07D 419/00 (2013.01); C07D 491/107 (2013.01); C07D 491/20 (2013.01);
Abstract

The invention relates to a compound of formula (1) in free form or in pharmaceutically acceptable salt form to pharmaceutical compositions comprising said compound and to the use of said compound in the treatment of heterotopic ossification and fibrodysplasia ossificans progressiva.

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