The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 11, 2025

Filed:

Jul. 14, 2022
Applicant:

Genzyme Corporation, Cambridge, MA (US);

Inventors:

Hanlan Liu, Lexington, MA (US);

Chris Willis, Southborough, MA (US);

Renu Bhardwaj, Ashland, MA (US);

Jianmei Kochling, Wellesley, MA (US);

Judith Peterschmitt, Watertown, MA (US);

Craig Siegel, Woburn, MA (US);

Assignee:

Genzyme Corporation, Cambridge, MA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/357 (2006.01); A61K 31/4025 (2006.01); A61K 45/06 (2006.01); A61P 3/00 (2006.01); A61P 3/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4025 (2013.01); A61K 31/357 (2013.01); A61K 45/06 (2013.01); A61P 3/00 (2018.01); A61P 3/06 (2018.01);
Abstract

The hemitartrate salt of a compound represented by the following structural formula: (Formula I Hemitartrate), which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of the Formula (I) Hemitartrate are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline Formula (I) Hemitartrate, and using it to inhibit glucosylceramide synthase or lowering glycosphingolipid concentrations in subjects to treat a number of diseases, are also discussed. Pharmaceutical compositions are also described.


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