The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 04, 2025
Filed:
Mar. 30, 2020
Shimadzu Corporation, Kyoto, JP;
The University of Tokyo, Tokyo, JP;
Naoki Kaneko, Kyoto, JP;
Taisuke Tomita, Tokyo, JP;
Yota Yoshizawa, Tokyo, JP;
Masaya Matsuzaki, Tokyo, JP;
Miyabishara Yokoyama, Tokyo, JP;
SHIMADZU CORPORATION, Kyoto, JP;
THE UNIVERSITY OF TOKYO, Tokyo, JP;
Abstract
The present invention provides a method for screening a substance that controls APP669 N-terminal cleavage activity, the method comprising: causing a candidate substance to act on a cultured cell; measuring an Aβ-related peptide produced from the cultured cell; and evaluating APP669 N-terminal cleavage activity. The candidate substance is selected, for example, from the group consisting of a low molecular weight compound, a peptide, a protein, and a nucleic acid. The present invention also provides an APP669 N-terminal cleavage enzyme containing ADAMTS4.