The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 04, 2025
Filed:
Mar. 01, 2022
Applicant:
Promega Corporation, Madison, WI (US);
Inventors:
Lance P. Encell, Fitchburg, WI (US);
Mary P. Hall, Waunakee, WI (US);
Keith V. Wood, Madison, WI (US);
Monika G. Wood, Madison, WI (US);
Assignee:
Promega Corporation, Madison, WI (US);
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/66 (2006.01); C12N 9/02 (2006.01); G01N 21/64 (2006.01); G01N 33/542 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/66 (2013.01); C12N 9/0069 (2013.01); G01N 21/6428 (2013.01); G01N 33/542 (2013.01); G01N 33/6803 (2013.01); C12Y 113/12007 (2013.01); G01N 2021/6432 (2013.01); G01N 2021/6439 (2013.01); G01N 2333/90241 (2013.01);
Abstract
Provided herein are isolated polynucleotide encoding modified click beetle luciferase polypeptides that have enhanced luminescence and longer wavelength near-infrared signals. The disclosure also relates to near-infrared bioluminescence systems that include said modified click beetle luciferase polypeptides and novel luciferin derivatives, as well as methods of using said modified click beetle luciferase polypeptides and bioluminescence systems.