The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 04, 2025
Filed:
Sep. 15, 2023
Applicant:
Melt&marble Ab, Gothenburg, SE;
Inventors:
Mingtao Huang, Gothenburg, SE;
Anastasia Krivoruchko, Gothenburg, SE;
Florian David, Gothenburg, SE;
Jens Nielsen, Gothenburg, SE;
Assignee:
Melt & Marble AB, Gothenburg, SE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 21/00 (2006.01); C07K 14/39 (2006.01); C07K 14/395 (2006.01); C12N 1/18 (2006.01); C12P 21/02 (2006.01);
U.S. Cl.
CPC ...
C12P 21/00 (2013.01); C07K 14/395 (2013.01); C12N 1/185 (2021.05); C12P 21/02 (2013.01);
Abstract
The present invention related to the provision of genetically modified fungal cells, such as yeast cells with an improved ability for producing and secreting different recombinant proteins. The improved ability is obtained by disruption in intracellular transport between the Golgi and the endosome. In particular embodiments, the disruption is achieved by downregulation or deletion of the gene encoding a Tda3p homolog. The fungal cell and method of the invention would allow for large-scale production of recombinant proteins in fungal cells.