The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 04, 2025
Filed:
Mar. 16, 2022
Applicant:
The Cleveland Clinic Foundation, Cleveland, OH (US);
Inventors:
Jianjun Zhao, Cleveland, OH (US);
Jianhong Lin, Cleveland, OH (US);
Assignee:
The Cleveland Clinic Foundation, Cleveland, OH (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); A61K 31/085 (2006.01); A61K 31/14 (2006.01); A61K 31/282 (2006.01); A61K 31/381 (2006.01); A61K 31/427 (2006.01); A61K 31/454 (2006.01); A61K 31/4985 (2006.01); A61K 31/506 (2006.01); A61K 31/519 (2006.01); A61K 31/549 (2006.01); A61K 31/7056 (2006.01); A61K 33/243 (2019.01); A61K 39/395 (2006.01); A61P 13/12 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1137 (2013.01); A61K 31/085 (2013.01); A61K 31/14 (2013.01); A61K 31/282 (2013.01); A61K 31/381 (2013.01); A61K 31/427 (2013.01); A61K 31/454 (2013.01); A61K 31/4985 (2013.01); A61K 31/506 (2013.01); A61K 31/519 (2013.01); A61K 31/549 (2013.01); A61K 31/7056 (2013.01); A61K 33/243 (2019.01); A61K 39/3955 (2013.01); A61P 13/12 (2018.01); C12N 2310/11 (2013.01);
Abstract
Provided herein are compositions, systems, articles of manufacture, and methods of treating a subject with: i) an APE2 inhibitor, and ii) a drug agent that causes increased expression of APE2 in said subject. In certain embodiments, the drug agent is Cisplatin or similar drug.