The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 04, 2025
Filed:
Jan. 28, 2022
Applicant:
Alnylam Pharmaceuticals, Inc., Cambridge, MA (US);
Inventors:
Anna Borodovsky, Melrose, MA (US);
Kallanthottathil G. Rajeev, Wayland, MA (US);
Kevin Fitzgerald, Brookline, MA (US);
Maria Frank-Kamenetsky, Brookline, MA (US);
William Querbes, Boston, MA (US);
Martin A. Maier, Belmont, MA (US);
Klaus Charisse, Acton, MA (US);
Satyanarayana Kuchimanchi, Acton, MA (US);
Muthiah Manoharan, Weston, MA (US);
Stuart Milstein, Arlington, MA (US);
Assignee:
Alnylam Pharmaceuticals, Inc., Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); A61K 31/7115 (2006.01); A61K 31/713 (2006.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01); A61K 47/54 (2017.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
C12N 15/1137 (2013.01); A61K 31/713 (2013.01); A61K 47/549 (2017.08); C12Y 304/21 (2013.01); C12N 2310/14 (2013.01); C12N 2310/312 (2013.01); C12N 2310/315 (2013.01); C12N 2310/321 (2013.01); C12N 2310/322 (2013.01); C12N 2310/343 (2013.01); C12N 2310/351 (2013.01); C12N 2310/3515 (2013.01); C12N 2320/35 (2013.01);
Abstract
The invention relates to RNAi agents, e.g., double-stranded RNAi agents, targeting the PCSK9 gene, and methods of using such RNAi agents to inhibit expression of PCSK9 and methods of treating subjects having a lipid disorder, such as a hyperlipidemia.