The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 04, 2025
Filed:
Jul. 04, 2020
Applicant:
Curevac SE, Tübingen, DE;
Inventor:
Andreas Thess, Kusterdingen, DE;
Assignee:
CureVac SE, Tübingen, DE;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); A61K 39/00 (2006.01); A61K 48/00 (2006.01); C12N 15/67 (2006.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 39/00 (2013.01); A61K 48/0008 (2013.01); C12N 15/67 (2013.01); C12N 15/85 (2013.01); A61K 2039/5156 (2013.01); A61K 2039/5256 (2013.01); A61K 2039/53 (2013.01); A61K 48/00 (2013.01); C12N 2310/531 (2013.01); C12N 2320/52 (2013.01); C12N 2840/105 (2013.01);
Abstract
The invention relates to an artificial nucleic acid molecule comprising at least one 5' UTR element which is derived from a TOP gene, at least one open reading frame, and preferably at least one histone stem-loop. Optionally the artificial nucleic acid molecule may further comprise, e.g. a poly(A)sequence, a poyladenylation signal, and/or a 3′ UTR. The invention further relates to the use of such an artificial nucleic acid molecule in gene therapy and/or genetic vaccination.