The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 04, 2025

Filed:

Nov. 19, 2021
Applicant:

Demetrix, Inc., Berkeley, CA (US);

Inventors:

Andrew Horwitz, Oakland, CA (US);

Jeff Wong, Berkeley, CA (US);

Darren Platt, San Francisco, CA (US);

Jeff Ubersax, San Francisco, CA (US);

Assignee:

Demetrix, Inc., Berkeley, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/52 (2006.01); C12N 9/02 (2006.01); C12N 15/81 (2006.01); C12P 7/22 (2006.01); C12P 17/06 (2006.01);
U.S. Cl.
CPC ...
C12N 9/0004 (2013.01); C12N 15/81 (2013.01); C12P 7/22 (2013.01); C12P 17/06 (2013.01); C12Y 121/03008 (2015.07);
Abstract

The present disclosure provides engineered variants of a cannabidiolic acid synthase (CBDAS) polypeptide comprising an amino acid sequence of SEQ ID NO:3 with one or more amino acid substitutions, nucleic acids comprising nucleotide sequences encoding said engineered variants, methods of making modified host cells comprising said nucleic acids, modified host cells expressing said engineered variants, methods of producing cannabinoids or cannabinoid derivatives, and methods of screening engineered variants of the cannabidiolic acid synthase (CBDAS) polypeptide.


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