The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 04, 2025
Filed:
Dec. 07, 2022
Matrix metalloprotease-cleavable and serine protease-cleavable substrates and methods of use thereof
Cytomx Therapeutics, Inc., South San Francisco, CA (US);
Stephen James Moore, Danville, CA (US);
Margaret Thy Luu Nguyen, San Francisco, CA (US);
Daniel Robert Hostetter, Palo Alto, CA (US);
Olga Vasiljeva, Cupertino, CA (US);
Jason Gary Sagert, San Mateo, CA (US);
Jonathan Alexander Terrett, Cupertino, CA (US);
James William West, Bend, OR (US);
CYTOMX THERAPEUTICS, INC., South San Francisco, CA (US);
Abstract
The invention relates generally to polypeptides that include at least a first cleavable moiety (CM1) that is a substrate for at least one matrix metalloprotease (MMP) and at least a second cleavable moiety (CM2) that is a substrate for at least one serine protease (SP), to activatable antibodies and other larger molecules that include these polypeptides that include at least a CM1 that is a substrate for at least one MMP protease and at least a CM2 that is a substrate for at least one SP protease, and to methods of making and using these polypeptides that include at least a CM1 that is a substrate for at least one MMP protease and at least a CM2 that is a substrate for at least one SP protease in a variety of therapeutic, diagnostic and prophylactic indications.