The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 04, 2025
Filed:
Nov. 22, 2017
Applicant:
The Regents of the University of California, Oakland, CA (US);
Inventors:
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/71 (2006.01); A61K 49/00 (2006.01); C07K 14/72 (2006.01); G01N 33/533 (2006.01); G01N 33/542 (2006.01); G01N 33/74 (2006.01);
U.S. Cl.
CPC ...
C07K 14/723 (2013.01); A61K 49/0008 (2013.01); A61K 49/0056 (2013.01); G01N 33/542 (2013.01); G01N 33/74 (2013.01); C07K 2319/60 (2013.01); G01N 2333/726 (2013.01);
Abstract
Provided are circularly permuted fluorescent protein sensors useful to integrate into the third intracellular loop of a G protein-coupled receptor (GPCR). Also provided are GPCRs having a circularly permuted fluorescent protein sensor integrated into its third intracellular loop and methods of using such GPCRs, e.g., to screen for GPCR agonists and antagonists and to monitor activation of GPCRs both in vitro and in vivo.