The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 04, 2025
Filed:
Jun. 23, 2022
Applicant:
Kite Pharma, Inc., Santa Monica, CA (US);
Inventors:
Stuart A. Sievers, Van Nuys, CA (US);
Jed J. W. Wiltzius, Winchester, MA (US);
Assignee:
Kite Pharma, Inc., Santa Monica, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 40/31 (2025.01); A61K 40/11 (2025.01); A61K 40/42 (2025.01); C07K 14/47 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); C07K 16/28 (2006.01); C12N 15/62 (2006.01); C12N 5/0783 (2010.01);
U.S. Cl.
CPC ...
C07K 14/4748 (2013.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/4205 (2025.01); A61K 40/4215 (2025.01); C07K 14/7051 (2013.01); C07K 14/70521 (2013.01); C07K 16/2878 (2013.01); C12N 15/62 (2013.01); A61K 2239/21 (2023.05); C07K 2317/31 (2013.01); C07K 2317/53 (2013.01); C07K 2317/55 (2013.01); C07K 2319/03 (2013.01); C07K 2319/75 (2013.01); C07K 2319/91 (2013.01); C12N 5/0638 (2013.01);
Abstract
The disclosure provides a chimeric antigen receptor (CAR) comprising a modified hinge, transmembrane and/or intracellular domain disclosed herein. Some aspects of the disclosure relate to a polynucleotide encoding a chimeric antigen receptor (CAR) comprising the costimulatory domain disclosed herein. Other aspects of the disclosure relate to cells comprising the CAR and use in a T cell therapy.