The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 04, 2025
Filed:
Dec. 20, 2019
Amgen Inc., Thousand Oaks, CA (US);
Nuria A Tamayo, Newbury Park, CA (US);
Abhisek Banerjee, Karnataka, IN;
James Alexander Brown, Moorpark, CA (US);
Michael J Frohn, Thousand Oaks, CA (US);
Jian Jeffrey Chen, San Diego, CA (US);
Kexue Li, Newbury Park, CA (US);
Qingyian Liu, Camarillo, CA (US);
Jonathan Dante Low, Reseda, CA (US);
Vu Ma, Oak Park, CA (US);
Liping H Pettus, Thousand Oaks, CA (US);
Mary Catherine Walton Cabrera, Camarillo, CA (US);
Ana Minatti, Los Angeles, CA (US);
Matthew Paul Bourbeau, Woodland Hills, CA (US);
Lei Jia, San Diego, CA (US);
Thomas T Nguyen, Newbury Park, CA (US);
Nobuko Nishimura, West Hills, CA (US);
Qiufen May Xue, Thousand Oaks, CA (US);
John Gordon Allen, Newbury Park, CA (US);
AMGEN INC., Thousand Oaks, CA (US);
Abstract
Compounds of formula (I): (I), as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.