The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 04, 2025
Filed:
Sep. 30, 2019
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, CN;
Xiaohua Chen, Shanghai, CN;
Jia Li, Shanghai, CN;
Yu Cheng, Shanghai, CN;
Yubo Zhou, Shanghai, CN;
Huijun Nie, Shanghai, CN;
Yujie Wang, Shanghai, CN;
Hongtao Tian, Shanghai, CN;
Weijuan Kan, Shanghai, CN;
Tian Mi, Shanghai, CN;
Xiaobei Hu, Shanghai, CN;
Binshan Zhou, Shanghai, CN;
Kenian Yan, Shanghai, CN;
Gaoya Xu, Shanghai, CN;
Yuhua Zhong, Shanghai, CN;
Lei Feng, Shanghai, CN;
Abstract
The present invention relates to a polysubstituted isoindoline compound as shown in general formula (I), and a preparation method, a pharmaceutical composition and the use thereof. In particular, the polysubstituted isoindoline compound is provided in the present invention as a class of novel CRL4E3 ubiquitin ligase modulators in structure, wherein same has a stronger antitumor activity and antitumor spectrum, and can be used to prepare drugs for treating CRL4E3 ligase-related diseases.