The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 04, 2025
Filed:
May. 22, 2023
Applicant:
Abcentra, Llc, Los Angeles, CA (US);
Inventors:
Bertrand C. Liang, San Diego, CA (US);
Stacey Ruiz, Beverly Hills, CA (US);
Christopher John Farina, Los Angeles, CA (US);
Assignee:
Abcentra, LLC, Los Angeles, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); A61P 9/10 (2006.01); A61P 29/00 (2006.01); A61K 39/00 (2006.01); C07K 14/775 (2006.01); C07K 16/18 (2006.01); G01N 33/53 (2006.01);
U.S. Cl.
CPC ...
A61K 39/3955 (2013.01); A61P 9/10 (2018.01); A61P 29/00 (2018.01); A61K 2039/505 (2013.01); C07K 14/775 (2013.01); C07K 16/18 (2013.01); C07K 2317/21 (2013.01); C07K 2317/34 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/90 (2013.01); G01N 33/53 (2013.01);
Abstract
Compositions and methods for treating rheumatoid arthritis and/or accelerated atherosclerosis are provided, including an inhibitor of oxidized or malondialdehyde-modified low density lipoprotein (LDL) for administration to a subject. Exemplary inhibitors of oxidized LDL include an anti-oxidized LDL antibody, which results in a reduction in the secretion of pro-inflammatory cytokine from primary monocyte in vitro and the plasma cytokine level of inflammatory cytokine in vivo.