The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 04, 2025

Filed:

Feb. 06, 2023
Applicant:

The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);

Inventors:

Peter Kwong, Washington, DC (US);

Rui Kong, Bethesda, MD (US);

Tongqing Zhou, Boyds, MD (US);

John Mascola, Rockville, MD (US);

Kai Xu, Bethesda, MD (US);

Cheng Cheng, Bethesda, MD (US);

Gwo-Yu Chuang, Rockville, MD (US);

Kevin Liu, Bethesda, MD (US);

Baoshan Zhang, Bethesda, MD (US);

Li Ou, Potomac, MD (US);

Wing-Pui Kong, Germantown, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 7/00 (2006.01); A61K 39/21 (2006.01); A61K 47/64 (2017.01); A61P 31/18 (2006.01); C07K 14/005 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/21 (2013.01); A61K 47/6415 (2017.08); A61K 47/643 (2017.08); A61K 47/646 (2017.08); A61P 31/18 (2018.01); C07K 14/005 (2013.01); C12N 7/00 (2013.01); A61K 2039/545 (2013.01); A61K 2039/6037 (2013.01); A61K 2039/6081 (2013.01); C07K 2319/40 (2013.01); C07K 2319/55 (2013.01); C12N 2740/16023 (2013.01); C12N 2740/16134 (2013.01); C12N 2740/16171 (2013.01);
Abstract

Embodiments of immunogens based on the HIV-1 Env fusion peptide and methods of their use and production are disclosed. Nucleic acid molecules encoding the immunogens are also provided. In several embodiments, the immunogens can be used to generate an immune response to HIV-1 Env in a subject, for example, to treat or prevent an HIV-1 infection in the subject.


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