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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12458688 B1

PDFFull Text
Date of Patent:
Nov. 04, 2025

Filed:

Sep. 11, 2019

Epitopes

Applicant:

Scancell Limited, Oxfordshire, GB;

Inventors:

Wei Xue, Oxfordshire, GB;

Katherine Wendy Cook, Oxfordshire, GB;

Linda Gillian Durrant, Oxfordshire, GB;

Victoria Anne Brentville, Oxfordshire, GB;

Assignee:

Scancell Limited, Oxford, GB;

Attorney:

Wolf, Greenfield & Sacks, P.C.

Primary Examiner:

Anne M Gussow

Assistant Examiner:

Sydney Van Druff

Int. Cl.
CPC ...
A61K 39/00 (2006.01); C07K 7/08 (2006.01); C07K 14/47 (2006.01); C07K 14/725 (2006.01); C12N 9/88 (2006.01);
U.S. Cl.
CPC ...
A61K 39/001176 (2018.08); A61K 39/0011 (2013.01); C07K 7/08 (2013.01); C07K 14/47 (2013.01); C07K 14/4702 (2013.01); C07K 14/4741 (2013.01); C07K 14/7051 (2013.01); C12N 9/88 (2013.01); C12Y 401/02013 (2013.01); C12Y 402/01011 (2013.01);
Abstract

The present invention relates to epitopes containing homocitrulline (Heit) that can be used as targets for cancer immunotherapy. The homocitrullinated T cell epitope has (i) a predicted binding score to MIC class II or class I of <30 using the online IEDB prediction program (http://www.iedb.org/) and (ii) at least 5 consecutive amino acids that form a spiral conformational structure. These modified peptides can be used as vaccines or as targets for T cell receptor (TCR) and adoptive T cell transfer therapies.

Find Patent Forward Citations

Xue, Wei. (2025). Epitopes (U.S. Patent No. 12458688). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12458688

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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