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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12458674 B1

PDFFull Text
Date of Patent:
Nov. 04, 2025

Filed:

May. 06, 2022

M13 phage based gene therapy platform

Applicant:

Massachusetts Institute of Technology, Cambridge, MA (US);

Inventors:

Uyanga Tsedev, Somerville, MA (US);

Angela M. Belcher, Lexington, MA (US);

Assignee:

Massachusetts Institute of Technology, Cambridge, MA (US);

Attorney:

Foley & Lardner LLP

Primary Examiner:

Robert S Cabral

Int. Cl.
CPC ...
A61K 35/76 (2015.01); A61K 47/69 (2017.01); A61K 48/00 (2006.01); A61K 49/00 (2006.01); A61P 35/00 (2006.01); C07K 14/005 (2006.01); C12N 1/10 (2006.01); C12N 7/00 (2006.01); C12P 21/02 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 35/76 (2013.01); A61K 47/6901 (2017.08); A61K 48/005 (2013.01); A61K 49/0097 (2013.01); A61P 35/00 (2018.01); C07K 14/005 (2013.01); C12N 1/105 (2021.05); C12N 7/00 (2013.01); C12P 21/02 (2013.01); A61K 38/00 (2013.01); C07K 2319/09 (2013.01); C07K 2319/33 (2013.01); C12N 2795/14122 (2013.01); C12N 2795/14132 (2013.01); C12N 2795/14152 (2013.01); C12N 2795/14171 (2013.01);
Abstract

An engineered phage-derived particle (PDP) for expressing a transgene in a target cell transduced with a bacteriophage, the PDP includes (i) less than about 500 bp of DNA from the bacteriophage genome, (ii) an ITR-flanked therapeutic gene up to 20 kb, (iii) an endosomal escape sequence, (iv) a nuclear localization sequence, and (v) a cell-specific targeting moiety. The PDP may escape lysosomal degradation, traffic across the nuclear envelope and expressed a therapeutic gene in a mammalian cell.

Find Patent Forward Citations

Tsedev, Uyanga. (2025). M13 phage based gene therapy platform (U.S. Patent No. 12458674). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12458674

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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