The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 04, 2025
Filed:
May. 06, 2022
Applicant:
Massachusetts Institute of Technology, Cambridge, MA (US);
Inventors:
Uyanga Tsedev, Somerville, MA (US);
Angela M. Belcher, Lexington, MA (US);
Assignee:
Massachusetts Institute of Technology, Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/76 (2015.01); A61K 47/69 (2017.01); A61K 48/00 (2006.01); A61K 49/00 (2006.01); A61P 35/00 (2006.01); C07K 14/005 (2006.01); C12N 1/10 (2006.01); C12N 7/00 (2006.01); C12P 21/02 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 35/76 (2013.01); A61K 47/6901 (2017.08); A61K 48/005 (2013.01); A61K 49/0097 (2013.01); A61P 35/00 (2018.01); C07K 14/005 (2013.01); C12N 1/105 (2021.05); C12N 7/00 (2013.01); C12P 21/02 (2013.01); A61K 38/00 (2013.01); C07K 2319/09 (2013.01); C07K 2319/33 (2013.01); C12N 2795/14122 (2013.01); C12N 2795/14132 (2013.01); C12N 2795/14152 (2013.01); C12N 2795/14171 (2013.01);
Abstract
An engineered phage-derived particle (PDP) for expressing a transgene in a target cell transduced with a bacteriophage, the PDP includes (i) less than about 500 bp of DNA from the bacteriophage genome, (ii) an ITR-flanked therapeutic gene up to 20 kb, (iii) an endosomal escape sequence, (iv) a nuclear localization sequence, and (v) a cell-specific targeting moiety. The PDP may escape lysosomal degradation, traffic across the nuclear envelope and expressed a therapeutic gene in a mammalian cell.