The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 04, 2025
Filed:
Feb. 01, 2019
Fred Hutchinson Cancer Center, Seattle, WA (US);
Stephen J. Tapscott, Seattle, WA (US);
Sean Shadle, Seattle, WA (US);
Amy Campbell, Seattle, WA (US);
Fred Hutchinson Cancer Center, Seattle, WA (US);
Abstract
Disclosed herein are methods of treating facioscapulohumeral muscular dystrophy (FSHD). In an example, a method of treatment includes administering to a subject an agent that increases NuRD and/or CAF-1 complex repression of DUX4, thereby reducing or inhibiting one or more signs or symptoms associated with muscular dystrophy. In other examples, the treatment method includes administering an agent that increases the activity and/or expression of NuRD/MBD2 and/or MBD1/CAF-1 complex members, thereby reducing or inhibiting one or more signs or symptoms associated with muscular dystrophy. Also disclosed is a method of treatment of FSHD including administering to a subject an effective amount of an MBD3L protein inhibitor to treat one or more signs or symptoms associated with FSHD.