The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 28, 2025

Filed:

Aug. 08, 2023
Applicants:

Virginia Commonwealth University, Richmond, VA (US);

New York University, New York, NY (US);

University of Bristol, Bristol, GB;

Inventors:

Jason Reed, Midlothian, VA (US);

Andrey Mikheykin, Richmond, VA (US);

Loren Picco, Bristol, GB;

Oliver Payton, Bristol, GB;

Freddie Russell-Pavier, Bristol, GB;

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01Q 20/02 (2010.01); C12N 9/22 (2006.01); C12N 15/11 (2006.01); C12Q 1/683 (2018.01); G01Q 60/42 (2010.01);
U.S. Cl.
CPC ...
G01Q 20/02 (2013.01); C12N 9/22 (2013.01); C12N 15/11 (2013.01); C12Q 1/683 (2013.01); G01Q 60/42 (2013.01); C12N 2310/20 (2017.05); C12N 2800/80 (2013.01); C12Q 2565/601 (2013.01);
Abstract

Exemplary embodiments of the present disclosure can include, for example, an atomic force microscopy (AFM) system, including a cantilever(s), an optical pickup unit(s) (OPU(s)) including a laser positioned over the cantilever(s), and a power source providing noise with a noise level that is below 300 Picometers. The noise level of the power source can be below 200 Picometers. A digitizing arrangement can be included which can be associated with the OPU. The digitizing arrangement(s) can have a bandwidth of about 2 MHZ. The OPU(s) can have a detection bandwidth of at least 80 MHZ. The exemplary apparatus can be combined with a chemical protocol and statistical signal processing and image analysis procedures to map DNA at high speed and accuracy.


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