The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 28, 2025
Filed:
Apr. 30, 2020
Applicant:
Suzhou Kunpeng Biotech Co., Ltd., Jiangsu, CN;
Inventors:
Assignee:
SUZHOU KUNPENG BIOTECH CO., LTD., Jiangsu, CN;
Primary Examiner:
Int. Cl.
CPC ...
C12P 21/02 (2006.01); C12N 1/20 (2006.01); C12N 9/00 (2006.01); C12N 15/70 (2006.01);
U.S. Cl.
CPC ...
C12P 21/02 (2013.01); C12N 1/20 (2013.01); C12N 9/93 (2013.01); C12N 15/70 (2013.01); C12Y 601/01006 (2013.01); C12N 2800/101 (2013.01);
Abstract
Provided by the present invention is a mutant lysyl-tRNA synthetase that has a deletion mutation at one or more sites selected from the group corresponding to the amino acid sequence of wild-type aminoacyl-tRNA synthetase: 102nd, 128th-140th, and 159th-179th amino acid residues. Compared with wild-type lysyl-tRNA synthetase, the mutant lysyl-tRNA synthetase according to the present invention has high activity, a high level of expression and good solubility, and may significantly increase the amount of an inserted unnatural amino acid and the level of expression of a target protein containing an unnatural amino acid.